Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma

Figure 4

Potential roles of CKS2 in HCC progression. (a) The possible roles of CKS2 in tumors were analyzed by the Cancer Hallmarks Analytics Tool. (b) Then, protein interaction analysis of CKS2 was predicted by the GeneMANIA tool. (c) GO annotations based on the top 116 upregulated and downregulated genes associated with CKS2 expression levels. (d) KEGG pathway analysis based on the top 116 upregulated and downregulated genes that were associated with CKS2 expression levels. (e) Gene set enrichment analysis (GSEA) of TCGA datasets elucidated that CKS2 was implicated in cell cycle and DNA replication pathways. (f) The correlation of CKS2 with proliferative markers CCNB1, PCNA, and Ki-67 was analyzed by the GEPIA tool. CKS2: cyclin-dependent kinase regulatory subunit 2; NES: normalized enrichment score.

(a)

(b)

(c)

(d)

(e)

(f)