Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma

Table 2

Univariate and multivariate analyses for identifying the risk factors of overall survival in 156 HCC patients.

Group	Univariate			Multivariate (gender and sex adjusted)
	HR		95% CI	HR		95% CI
Gender
Male vs. female	1.315	0.411	0.685-2.524
Age (years)
≤50 vs. >50	0.754	0.155	0.510-1.113
Tumor diameter (cm)
≤5 vs. >5	3.060	<0.001	2.038-4.595	1.706	0.021	1.085-2.684
Differentiation
Well vs. moderate & poor	1.886	0.008	1.184-3.005	1.567	0.068	0.968-2.538
AFP (ng/mL)
≤50 vs. >50	1.799	0.005	1.191-2.716	1.448	0.095	0.937-2.235
Liver cirrhosis
Yes vs. no	1.010	0.963	0.654-1.561
Portal vein invasion
Yes vs. no	2.068	0.001	1.357-3.151	1.919	0.007	1.196-3.078
HBsAg
Yes vs. no	2.340	0.011	1.217-4.499	1.279	0.494	0.632-2.587
TNM
I-II vs. III-IV	4.468	<0.001	2.950-6.766	2.393	0.001	1.445-3.963
Metastasis
Yes vs. no	3.016	<0.001	1.917-4.745	1.304	0.327	0.767-2.219
CKS2 expression
High vs. low	5.668	<0.001	2.943-10.916	2.088	0.014	1.161-3.754

CKS2: cyclin-dependent kinase regulatory subunit 2; TNM: tumor node metastasis; AFP: alpha-fetoprotein. Bold: .