Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma

Table 3

Univariate and multivariate analyses for identifying the risk factors of disease-free survival in 156 HCC patients.

Group	Univariate			Multivariate (gender and sex adjusted)
	HR		95% CI	HR		95% CI
Gender
Male vs. female	1.230	0.498	0.675-2.240
Age (years)
≤50 vs. >50	0.746	0.125	0.513-1.085
Tumor diameter (cm)
≤5 vs. >5	2.622	<0.001	1.782-3.860	1.434	0.131	0.898-2.288
Differentiation
Well vs. moderate & poor	1.486	0.074	0.962-2.295
AFP (ng/mL)
≤50 vs. >50	1.660	0.012	1.120-2.460	1.403	0.108	0.929-2.119
Liver cirrhosis
Yes vs. no	0.903	0.642	0.588-1.387
Portal vein invasion
Yes vs. no	1.565	0.025	1.057-2.315	1.614	0.038	1.028-2.536
HBsAg
Yes vs. no	2.088	0.021	1.118-3.898	1.216	0.574	0.615-2.403
TNM
I-II vs. III-IV	4.030	<0.001	2.697-6.022	2.702	<0.001	1.608-4.539
Metastasis
Yes vs. no	2.370	<0.001	1.531-3.668	0.846	0.534	0.499-1.434
CKS2 expression
High vs. low	2.210	0.003	1.316-3.711	2.511	0.002	1.414-4.458

CKS2: cyclin-dependent kinase regulatory subunit 2; TNM: tumor node metastasis; AFP: alpha-fetoprotein. Bold: .