Disease Markers

Research Article

A Nomogram Based on Clinicopathologic Features and Preoperative Hematology Parameters to Predict Occult Peritoneal Metastasis of Gastric Cancer: A Single-Center Retrospective Study

Table 2

Univariate analysis of preoperative hematology parameters in groups with or without occult peritoneal metastasis.


Various	Training group		value	Validation group		value
Various	OPM (+)	OPM (-)	value	OPM (+)	OPM (-)	value

NLR			<0.001			0.797
<2	20 (27.4)	224 (49.4)		9 (11.7)	68 (52.3)
≥2	53 (72.6)	229 (50.6)		7 (10.1)	62 (47.7)
PLR			<0.001			0.585
<165	33 (45.2)	302 (66.7)		9 (56.3)	84 (64.6)
≥165	40 (54.8)	151 (33.3)		7 (13.2)	46 (35.4)
CEA			0.049			0.530
<2.5 ng/mL	49 (67.1)	352 (77.7)		11 (68.8)	101 (77.7)
≥2.5 ng/mL	24 (32.9)	101 (22.3)		5 (31.3)	29 (22.3)
CA199			0.001			0.521
<30 U/mL	46 (63.0)	364 (80.4)		14 (87.5)	109 (83.8)
≥30 U/mL	27 (37.0)	89 (19.6)		2 (12.5)	21 (16.2)
CA125			<0.001			0.003
<14 U/mL	16 (21.9)	329 (72.6)		3 (18.8)	77 (59.2)
≥14 U/mL	57 (78.1)	124 (27.4)		13 (81.3)	53 (40.8)
GPS			<0.001			0.001
0	20 (27.4)	196 (43.3)		3 (18.8)	44 (33.8)
1	34 (46.6)	230 (50.8)		5 (31.3)	79 (60.8)
2	19 (26.0)	27 (6.0)		8 (53.3)	7 (5.4)
PT			0.811			0.670
<12 sec	54 (74.0)	341 (75.3)		14 (87.5)	117 (90.0)
≥12 sec	19 (26.9)	112 (24.7)		2 (12.5)	13 (10.0)
APTT			0.467			0.566
<28 sec	44 (60.3)	293 (64.7)		10 (62.5)	92 (70.8)
≥28 sec	29 (39.7)	160 (35.3)		6 (37.5)	38 (29.2)
TT			0.219			0.786
<18 sec	47 (64.4)	257 (56.7)		11 (68.8)	82 (63.1)
≥18 sec	26 (35.6)	196 (43.3)		5 (31.3)	48 (36.9)
FIB			<0.001			0.005
<3 g/L	26 (35.6)	278 (61.4)		4 (25.0)	83 (63.8)
≥3 g/L	47 (64.6)	175 (38.6)		12 (75.0)	47 (36.2)
D-dimer			0.078			0.054
<0.5 mg/L	36 (49.3)	273 (60.3)		6 (37.5)	84 (64.6)
≥0.5 mg/L	37 (50.7)	180 (39.7)		10 (62.5)	46 (35.4)

OPM (+): with occult peritoneal metastasis; OPM (-): without occult peritoneal metastasis; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-to-lymphocyte ration; CEA: carcinoembryonic antigen; CA199: carbohydrate antigen 19-9; CA125: carbohydrate antigen 125; GPS: Glasgow prognosis score; PT: prothrombin time; APTT: activated partial thromboplastin time; TT: thrombin time; FIB: fibrinogen.