Identification of Serum CMTM2 as a Potential Biomarker for HBV-Related Disorders

Figure 7

Correlation between CMTM2 and hepatocellular carcinoma progression. The Cell Counting Kit-8 assays showed that knockdown of CMTM2 promoted the cell growth, and cell growth was inhibited by overexpression of CMTM2 (a, b). Annexin V/PI-staining indicated that CMTM2 did not induce apoptosis of HepG2 cells (c, d). Knockdown of CMTM2 decreased the G2/M phase accumulation and overexpressed CMTM2 increased the G2/M phase population (e, f). Knockdown of CMTM2 could promote cell migration and invasion which were examined by Transwell migration and invasion assays (g). Overexpressed CMTM2 could inhibit cell migration and invasion of HepG2 cells which determined by Transwell migration and invasion assays (h). p <0.05.

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