Research Article

Identification of Protein Expression Changes in Hepatocellular Carcinoma through iTRAQ

Table 2

List of the 41 differentially expressed proteins in HCC.

No.AccessionDescriptionCoverageProteinsUnique peptidesFold change cancer/normal

1B2R950cDNA, FLJ94213, highly similar to Homo sapiens pregnancy zone protein (PZP), mRNA9.99690.5155859
2P01023Alpha-2-macroglobulin41.937421.9621536
3A8K5T0cDNA FLJ75416, highly similar to Homo sapiens complement factor H (CFH), mRNA51.34511.2850993
4P02656Apolipoprotein C-III34.34230.661148
5P01009Alpha-1-antitrypsin26.5618101.7751413
6B0AZL7cDNA, FLJ79457, highly similar to insulin-like growth factor binding protein complex acid labile chain35.873180.7544295
7A8K2T4cDNA FLJ78207, highly similar to human complement protein component C7 mRNA50.77621.6921352
8P06727Apolipoprotein A-IV72.2238251.3346624
9Q6LAN8Collagen type I alpha 1 (fragment)1.68320.3289969
10P27169Serum paraoxonase/arylesterase 118.871060.7979568
11Q86TT2Full-length cDNA clone CS0DI019YF20 of the placenta of Homo sapiens (human) (fragment)24.582051.3549255
12A6XND1Insulin-like growth factor binding protein 3 isoform b13.311830.8091975
13K7ER74Apolipoprotein C-IV33.15650.7221412
14H3BRJ9Cholesteryl ester transfer protein3.5510.7701269
15P0CG05Ig lambda-2 chain C regions50.944731.2929291
16K7ERI9Truncated apolipoprotein C-I (fragment)23.38620.6776806
17B2R773cDNA, FLJ93312, highly similar to Homo sapiens adipose most abundant gene transcript 1 (APM1), mRNA6.15211.2836387
18Q8N567Zinc finger CCHC domain-containing protein 912.92112.205296
19P51884Lumican40.242121.2781468
20D3JV41Thrombocidin-2 antimicrobial variant (fragment)38.1450.7778097
21Q59GZ2PLEK protein variant (fragment)1.95210.7092328
22Q5T0R7Adenylyl cyclase-associated protein (fragment)7.471410.8056854
23P02741C-reactive protein23.66360.7119999
24Q68CK4Leucine-rich alpha-2-glycoprotein43.8210.7878539
25P02747Complement C1q subcomponent subunit C15.92131.2504316
26B4DTB1cDNA FLJ52936, weakly similar to tropomyosin alpha-4 chain20.783520.7363925
27Q7LC44Activity-regulated cytoskeleton-associated protein2.78111.4207039
28D6R904Tropomyosin alpha-3 chain23.163710.8191275
29I2D5I8Apolipoprotein M (fragment)15.12420.7276038
30Q6NSB4HP protein9.61830.8037301
31J3KRP0Beta-Ala-His dipeptidase7.76430.8289956
32B7Z590Cadherin-133.41311.295513
33A6NIW5Peroxiredoxin 2, isoform CRA_a19.85321.2729786
34C9JUM4EGF-containing fibulin-like extracellular matrix protein 1 (fragment)20.97811.3872657
35P08603Complement factor H52.15720.7693435
36K7EJ44Profilin 1, isoform CRA_b26.92220.7312391
37B2RA39cDNA, FLJ94686, highly similar to Homo sapiens complement factor H-related 5 (CFHL5), mRNA3.87410.803087
38P01011Alpha-1-antichymotrypsin40.194140.802004
39B2RAL6cDNA, FLJ94991, highly similar to Homo sapiens integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide) (ITGAL), mRNA0.6210.8038053
40J3QSE5Phosphatidylcholine-sterol acyltransferase (fragment)9.8420.7909272
41B4E1C4cDNA FLJ51179, highly similar to vitamin K-dependent protein C (EC 3.4.21.69)16.631640.8316701