Low UGP2 Expression Is Associated with Tumour Progression and Predicts Poor Prognosis in Hepatocellular Carcinoma

Table 2

Univariate and multivariate Cox regression analyses of risk factors for overall survival time in the ZZU HCC cohort.

Variable	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Sex (male vs. female)	1.145 (0.715-1.831)	0.573
Age (<50 vs. ≥50 years)	0.968 (0.651-1.440)	0.874
Liver cirrhosis (absent vs. present)	1.557 (0.834-2.907)	0.165
AFP (≥20 ng/ml vs. <20 ng/ml)	0.760 (0.516-1.120)	0.165
Tumour multiplicity (single vs. multiple)	1.023 (0.653-1.604)	0.919
Maximal tumour size (<5 cm vs. ≥5 cm)	1.019 (0.694-1.497)	0.923
Portal vein thrombosis (absence vs. gross)	0.543 (0.327-0.903)	0.019	0.987 (0.566-1.721)	0.963
TNM stage (I-II vs. III-IV)	0.317 (0.213-0.472)	0.000	0.332 (0.215-0.513)	0.000
UGP2 level (low vs. high)	1.873 (1.245-2.819)	0.003	1.754 (1.162-2.648)	0.007

Notes: , . Abbreviations: AFP: alpha-fetoprotein; TNM: tumour-node-metastasis; HR: hazard ratio; CI: confidential interval.