Novel Value of Preoperative Gamma-Glutamyltransferase Levels in the Prognosis of AFP-Negative Hepatocellular Carcinoma
Table 1
Clinical characteristics of patients.
Variables
()
and ()
()
value
Age (years)
0.060
Sex
<0.001
Male
181 (85.8)
305 (95.3)
142 (96.6)
Female
30 (14.2)
15 (4.7)
5 (3.4)
Cause of disease
0.702
HBV
179 (84.8)
278 (86.9)
126 (85.7)
HCV
2 (0.9)
7 (2.2)
4 (2.7)
Others
31 (14.7)
40 (12.5)
19 (12.9)
Platelet count (109/L)
0.448
Liver cirrhosis
0.167
Present
112 (53.1)
195 (60.9)
89 (60.5)
Absent
99 (46.9)
125 (39.1)
58 (39.5)
Albumin (g/L)
0.051
Serum total bilirubin (μmol/L)
0.424
ALBI grade
1
183 (86.7)
254 (79.4)
115 (78.2)
0.055
2
28 (13.3)
66 (20.6)
32 (21.8)
Tumor size (cm)
<0.001
Tumor number
0.009
≤1
190 (90.0)
263 (82.2)
116 (78.9)
>1
21 (10.0)
57 (17.8)
31 (21.1)
Tumor extent
0.119
Unilobar
206 (97.6)
303 (94.7)
137 (93.2)
Bilobar
5 (2.4)
17 (5.3)
10 (6.8)
Microvascular invasion
0.001
Absent
189 (89.6)
268 (83.8)
109 (74.1)
Present
22 (10.4)
52 (16.2)
38 (25.9)
Surgical time (min)
0.065
Type of hepatectomy†
0.107
Major
36 (17.1)
61 (19.1)
38 (25.9)
Minor
175 (82.9)
259 (80.9)
109 (74.1)
Surgical margin‡ (cm)
0.062
<1
73 (34.6)
136 (42.5)
68 (46.3)
≥1
138 (65.4)
184 (57.5)
79 (53.7)
Intraoperative blood loss (mL)
<0.001
<400
160 (75.8)
217 (67.8)
71 (48.3)
≥400
51 (24.2)
103 (32.2)
76 (51.7)
Encapsulation
0.414
Complete
104 (49.3)
149 (46.6)
62 (42.2)
Incomplete
107 (50.7)
171 (53.4)
85 (57.8)
Tumor differentiation
0.235
Well
48 (22.7)
57 (17.8)
24 (16.3)
Moderate or poor
163 (77.3)
263 (82.2)
123 (83.7)
BCLC stage
<0.001
A
200 (94.8)
288 (90.0)
121 (82.3)
B
10 (4.7)
27 (8.4)
8 (5.4)
C
1 (0.5)
5 (1.6)
18 (12.3)
Variables are expressed as no. (%). HBV: hepatitis B virus; HCV: hepatitis C virus; ALBI grade: albumin-bilirubin grade; BCLC: Barcelona Clinic Liver Cancer. †Major liver resection: resection with more than two lobes; minor liver resection: resection with no more than two lobes. ‡Surgical margin: the shortest measured distance from the edge of the tumor to the plane of liver transection.
