Research Article
Association of Soluble Klotho Level with Adverse Outcomes in Patients on Maintenance Hemodialysis
Table 1
Comparison of demographic and clinical data in enrolled patients on MHD.
| | Variables | Total
() |
ng/ml () |
ng/ml () | value |
| | Ages | | | | 0.283 | | Male (%) | 116 (55.0) | 55 (52.4) | 61 (57.5) | 0.451 | | Diabetes (%) | 16249 (23.3) | 23 (21.9) | 26 (24.5) | 0.652 | | Hypertension (%) | 179 (84.8) | 88 (83.1) | 91 (85.5) | 0.680 | | ACEI/ARB (%) | 168 (79.6) | 82 (78.1) | 86 (81.1) | 0.584 | | Vitamin D (%) | 176 (83.6) | 81 (77.1) | 95 (89.6) | 0.015 | | Dialysis vintage (year) | | | | 0.005 | | Scr (μmol/L) | | | | 0.016 | | Bun (mmol/L) | | | | 0.837 | | KT/V (per week) | | | | 0.682 | | HGB (g/L) | | | | 0.337 | | Ca (mmol/L) | | | | 0.136 | | P (mmol/L) | | | | 0.942 | | (mg2/dL2) | | | | 0.667 | | ALB (g/L) | | | | 0.337 | | iPTH (pg/mL) | 285.2 (137.2, 568.4) | 273.4 (126.4, 572.3) | 316.5 (163.0, 561.3) | 0.530 | | Klotho (ng/mL) | 1.34 (0.66, 1.95) | 0.66 (0.39, 0.93) | 1.95 (1.61, 2.26) | <0.001 | | FGF23 (pg/mL) | 515.3 (401.0, 661.4) | 582.6 (450.6, 698.3) | 482.8 (352.5, 598.6) | 0.007 |
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Abbreviations: MHD: maintenance hemodialysis; Scr: serum creatinine; Ca: calcium; P: phosphorus; Bun: blood urea nitrogen; ALB: albumin; HGB: hemoglobin; ACEI: angiotensin-converting enzyme inhibitors; ARB: angiotensin receptor blockers; iPTH: intact parathyroid hormone; FGF23: fibroblast growth factor 23. Data are presented as for normally distributed variables, otherwise median with 25 th-75th percentile. |
