Association of Soluble Klotho Level with Adverse Outcomes in Patients on Maintenance Hemodialysis

Table 4

Multivariate Cox regression for cardiovascular events and combined adverse events.

Models	Cardiovascular events		Combined adverse events
	HR (95% CI)	value	HR (95% CI)	value
Model 1	2.235 (1.248-4.003)	0.007	2.248 (1.393-3.625)	0.001
Model 2	2.201 (1.228-3.944)	0.008	2.072 (1.279-3.356)	0.003
Model 3	1.986 (1.066-3.701)	0.031	1.824 (1.106-3.010)	0.019
Model 4	1.942 (1.030-3.661)	0.040	1.818 (1.092-3.026)	0.021

Model 1: crude; Model 2: adjustment for age; Model 3: Model 2 plus adjustment for diabetes and dialysis vintage; Model 4: Model3 plus adjustment for albumin and FGF23.