ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Figure 1

(a) The expression patterns of GC tumors () and normal GC tissues () based on The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) data in the GEPIA database (http://gepia2.cancer-pku.cn/#analysis). (b) The expression of ZNF143 in GC tumors and corresponding normal tissues using immunohistochemical staining. (c, d) Expression of ZNF143 in HGC27 cells transfected with sh-ZNF143 and in BGC823 cells transfected with LV-ZNF143 lentivirus. (c) The expression of ZNF143 in HGC27 and BGC823 cells analyzed using Western blot analysis. (d) Expression of ZNF143 detected by real-time PCR in HGC27 and BGC823 cells. (e, f) Expression of ZNF143 in HGC27 and BGC823 cells examined using immunofluorescence. , , and . The data were expressed as . GC: gastric cancer; ZNF143: zinc finger protein 143; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; DAPI: 4,6-diamidino-2-phenylindole dihydrochloride.

(a)

(b)

(c)

(d)

(e)

(f)