Research Article

ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis

Figure 3

ZNF143 inhibited cell cycle arrest in the G1 phase and the apoptosis of GC cells. (a, b) Cell cycle distribution of GC cells measured using flow cytometry. (c) Percentage of G1 phase. (d) Protein expression of CDC6, PLK1, MCM2, and MCM4 detected using Western blot analysis. (e, f) Apoptotic rate of GC cells measured using flow cytometry. (g) Apoptotic rate of GC cells. (h) Protein expression levels of p53, Bcl-2, Bax-cl, and Bax detected using Western blot analysis. , , and . The data were expressed as . CDC6: cell division cycle 6; PLK1: polo-like kinase 1; MCM2: minichromosome maintenance complex component 2; MCM4: minichromosome maintenance complex component 4; p53: tumor protein 53; Bcl-2: B-cell lymphoma-2; Bcl-xl: BCL2-like 1; Bax: BCL2 associated X; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.
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