Diagnosis Test Meta-Analysis for Apolipoprotein E in Alzheimer’s Disease

Table 1

Main characteristics of the studies included in the meta-analysis.

Study	Year	Country	Ethnicity	The way for diagnosis	Number of true positive cases	Number of false positive cases	False negative cases	True negative cases	The design of experiment	The blind method	QUADAS-2 score
Zheng [7]	2014	China	Asian	CCMD-3	76	19	42	90	Case-control	NM	10
Zhou [8]	2011	China	Asian	CMMSE	209	31	149	220	Case-control	NM	9
Sando [9]	2008	Norway	Caucasian	NINCDS-ADRDA	376	125	160	561	Case-control	NM	10
Sunderland [10]	2004	USA	Whites	MMSE, CDR, GDS, DRS	150	52	63	142	Cross-sectional	NM	10
Lai [11]	2001	China	Asian	DSM-III-R, NINCDS-ADRDA	110	61	97	518	Cross-sectional	NM	10
Ganguli [12]	2000	USA	Monongahela Valley	NINCDS-ADRDA	247	107	184	639	Case-control	YES	11
Ganguli [12]	2000	USA	Ballabgarh	NINCDS-ADRDA	64	581	62	4386	Case-control	YES	11
Tang [13]	1998	USA	African Americans	CDR	53	45	36	128	Cross-sectional	NM	10
Tang [13]	1998	USA	Whites	CDR	23	49	17	214	Cross-sectional	NM	10
Tang [13]	1998	USA	Hispanics	CDR	145	115	110	516	Cross-sectional	NM	10
Nunomura [14]	1996	Japan	Asian	CT/MRI, ICD-10	72	12	36	83	Case-control	NM	9
Xiao [15]	1994	Japan	Asian	NINCDS-ADRDA	88	15	38	93	Case-control	NM	10
Rebeck [16]	1993	USA	Whites	Biopsy	39	6	16	35	Case-control	NM	8

CMMSE: Chinese Mini-Mental State Examination; CCMD-3: Chinese Classification and Diagnosis of Mental Diseases-3rd; NINCDS-ADRDA: National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association; ICD-10: International Classification of Diseases 10th Edition; MMSE: Mini-Mental State Examination; CDR: Clinical Dementia Rating; GDS: Global Deterioration Scale; DRS: Dementia Rating Scale; DSM-III-R: Diagnostic and Statistical Manual of Mental Disorders-III-R; CT: Computed Tomography; MRI: Magnetic Resonance Imaging; NM: not mentioned.