Diagnosis Test Meta-Analysis for Apolipoprotein E in Alzheimer’s Disease

Table 2

Metaregression and subgroup analysis.

Variable	Category	Number of study	Sensitivity (95% CI)		Specificity (95% CI)
Diagnostic criteria	Checklist	11	0.62 (0.58-0.66)	0.01	0.83 (0.81-0.86)	≤0.001
	Non-checklist	2	0.69 (0.58-0.79)		0.87 (0.79-0.94)
Experimental design	Case-control	8	0.63 (0.58-0.68)	0.04	0.85 (0.82-0.88)	≤0.001
	Cross-sectional	5	0.61 (0.54-0.67)		0.81 (0.77-0.85)
Blind	No	11	0.64 (0.60-0.67)	0.68	0.83 (0.80-0.85)	≤0.001
	Yes	2	0.55 (0.46-0.63)		0.87 (0.83-0.91)
Sample size	≥300	6	0.59 (0.54-0.63)	≤0.001	0.86 (0.84-0.88)	≤0.001
	<300	7	0.66 (0.62-0.71)		0.80 (0.77-0.84)