Disease Markers

Research Article

Elevated Levels of Serum Neurofilament Light Chain Associated with Cognitive Impairment in Vascular Dementia

Table 1

Clinical and biochemical characteristics of all the subjects.


Variables	NC	VaD

	80	96	—
Age (years)			0.742
Gender (male/female)	49/31	60/36	0.865
Serum NfL (pg/mL)			<0.001
Education (years)			0.037
Smoking (, %)	19 (23.75)	24 (25.00)	0.848
Alcohol (, %)	27 (33.75)	30 (31.25)	0.724
CHD (, %)	10 (12.50)	13 (13.54)	0.838
HBP (, %)	24 (30.00)	29 (30.21)	0.976
SBP (mmHg)			0.519
DBP (mmHg)			0.743
HLP (, %)	17 (21.25)	20 (20.83)	0.946
TC (mmol/L)			0.286
TG (mmol/L)			0.451
HDL-C (mmol/L)			0.325
LDL-C (mmol/L)			0.098
DM (, %)	14 (17.50)	16 (16.67)	0.884
FBG (mmol/L)			0.356
MoCA (points)			<0.001

NC: normal controls; VaD: vascular dementia; NfL: neurofilament light chain; CHD: coronary heart disease; HBP: high blood pressure; SBP: systolic blood pressure; DBP: diastolic blood pressure; HLP: hyperlipidemia; TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; DM: Diabetes Mellitus; FBG: fasting plasma glucose; MoCA: Montreal cognitive assessment scale.