Identification of PDL1-Related Biomarkers to Select Lung Adenocarcinoma Patients for PD1/PDL1 Inhibitors
Table 1
PDL1 coexpressed genes not only differentially expressed in lung adenocarcinoma but also contribute to overall survival.
mRNA
Cor
log2foldchange
value
ANLN
0.36109
3.77289
5.92E-05
ARNTL2
0.3383
2.4906
0.00144954
AVL9
0.31527
1.08517
0.04576124
BRCA1
0.3755
1.46278
0.005052667
BRIP1
0.32595
2.68693
0.04478685
CD53
0.37628
-1.0313
0.005429641
CENPE
0.32484
2.65322
0.006552998
CRTAM
0.37113
-1.0706
0.02319598
CSF2RB
0.32911
-1.0044
0.008033928
CYBB
0.46179
-1.3471
0.01465277
DOCK11
0.42634
-1.2654
0.01724113
ELOVL6
0.41838
1.28021
0.01821207
EREG
0.51626
2.58762
0.003137182
FCGR1B
0.346
-1.0663
0.01076134
GIMAP4
0.37656
-1.4853
0.001781643
GIMAP5
0.34985
-1.6241
0.006549764
GPR65
0.37454
-1.1182
0.03443263
GPX3
0.34227
-2.2637
0.009965236
GSG2
0.31185
1.92806
0.04657218
HACD4
0.37455
-1.4402
0.002306662
KIAA1524
0.33152
1.96877
0.01320607
KIF20B
0.34274
1.29505
0.02865572
KRT80
0.32673
2.43778
0.01169369
LPXN
0.33821
-1.1081
0.004965741
LRRC8C
0.33574
-1.12
0.0407523
MELK
0.35309
3.61062
0.01053599
MNDA
0.35278
-1.4709
0.02036211
NCAPG2
0.31191
1.77961
0.003450744
NCKAP1L
0.37919
-1.2778
0.003063421
NGEF
0.31071
3.00327
0.01781168
PLK4
0.32713
2.03832
0.01624677
PMAIP1
0.40395
1.63802
0.03528504
RALGPS2
0.31509
1.65783
0.02929378
RGS20
0.35033
2.9063
0.009297155
SCIMP
0.31898
-1.5645
0.000474133
SHCBP1
0.42305
2.27346
0.001114681
SMCO2
0.33114
2.49326
0.002347819
TLR4
0.35033
-1.5721
0.0217862
TRIM6
0.31406
1.16306
0.01236621
Cor: correlation coefficient; log2foldchange: negative number represents downregulation, positive number represents upregulation; value: overall survival of patients in log-rank test.
