CTLA-4 +49A/G Polymorphism Increases the Susceptibility to Bladder Cancer in Chinese Han Participants: A Case-Control Study

Table 2

Logistic regression analysis of associations between CTLA-4 +49A/G polymorphism and risk of bladder cancer.

Genotype	^#Cases ()		^#Controls ()		OR (95% CI)		OR (95% CI)
		%		%
AA	206	58.2%	288	66.3%	1.00		1.00
AG	127	35.9%	132	30.5%	1.35 (0.99-1.82)	0.055	1.35 (1.00-1.82)	0.054
GG	21	5.9%	14	3.2%	2.10 (1.04-4.22)	0.038	2.10 (1.04-4.23)	0.038
	148	41.8%	146	33.7%	1.42 (1.06-1.89)	0.019	1.42 (1.06-1.90)	0.018
	333	94.1%	420	96.8%	1.00		1.00
GG	21	5.9%	14	3.2%	1.89 (0.95-3.78)	0.071	1.90 (0.95-3.79)	0.070
A allele	539	76.13%	708	81.6%	1.00		1.00
G allele	169	23.87%	160	18.4%	1.39 (1.09-1.77)	0.008	—	—

^#The genotyping was successful in 354 cases and 434 controls for CTLA4 +49A/G; bold values are statistically significant (). Adjustments for age and sex.