In Vitro and In Vivo Efficacy of DNA Damage Repair Inhibitor Veliparib in Combination with Artesunate against Echinococcus granulosus

Figure 5

Oxidative DNA damage in cysts exposed to different concentrations of drugs in vivo, as determined by 8-OHdG immunofluorescence. The mice were treated with ABZ (200 mg/kg/d), AS-H (200 mg/kg/d), and AS-H+Veliparib (25 mg/kg/d). Hoechst was used for nuclear staining. Parts showing positive 8-OHdG nuclei (green). V: Veliparib.