Serum Clusterin: A Potential Marker for Assessing the Clinical Severity and Short-Term Prognosis of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure

<div>Comparisons of serum clusterin levels among different groups. (a) The levels of serum clusterin in HBV-ACLF and HBV-non-ACLF patients and normal controls. (b) The levels of serum clusterin in HBV-ACLF patients with different levels of PTA. (c) The levels of serum clusterin in HBV-ACLF patients with different levels of TBIL. (d) The levels of serum clusterin in HBV-non-ACLF patients with different levels of TBIL. (e) The levels of serum clusterin in HBV-ACLF survival and nonsurvival groups. (f) The levels of serum clusterin in HBV-ACLF patients with <svg height="10.4277pt" id="M80" style="vertical-align:-1.1198pt" version="1.1" viewbox="-0.0498162 -9.3079 94.9427 10.4277" width="94.9427pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M319 325C317 349 306 409 297 431C277 440 250 449 209 449C117 449 57 389 57 319C57 243 122 209 182 182C232 159 261 135 261 91C261 48 227 21 190 21C130 21 85 79 68 145L41 140C41 104 51 36 58 22C75 7 121 -12 172 -12C252 -12 337 35 337 126C337 195 286 231 210 262C166 281 126 304 126 348C126 388 152 417 191 417C240 417 274 378 294 318L319 325Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.706,0)"><path d="M518 50L491 51C452 54 444 60 444 110V444C429 441 405 437 377 434C348 430 314 427 287 426V403L323 397C356 392 365 386 365 333V99C331 66 293 51 257 51C212 51 169 75 169 164V299C169 366 169 413 172 444C156 441 128 437 101 433C75 430 50 427 29 426V403L57 397C82 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Abbreviations: HBV-ACLF: hepatitis B virus-related acute-on-chronic liver failure; PTA: prothrombin activity; TBIL: total bilirubin.</div>

Disease Markers

fig1

Figure 1

Figure 1: Serum Clusterin: A Potential Marker for Assessing the Clinical Severity and Short-Term Prognosis of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure 

Figure 1 | Serum Clusterin: A Potential Marker for Assessing the Clinical Severity and Short-Term Prognosis of Hepatitis B Virus-Related Acute-on-Chronic Liver Failure 