Associations between Interleukin-32 Gene Polymorphisms rs12934561 and rs28372698 and Susceptibilities to Bladder Cancer and the Prognosis in Chinese Han Population
Table 3
Distribution of SNPs in IL-32 among patients and controls and their association with bladder cancer risk.
rs28372698
rs12934561
Model
Genotype
Patients (%)
Controls (%)
OR (95% CI)
Genotype
Patients (%)
Controls (%)
OR (95% CI)
Codominant
AA
144 (44.9%)
215 (49.2%)
1.00 (reference)
TT
127 (39.6%)
151 (34.5%)
1.00 (reference)
AT
147 (45.8%)
193 (44.2%)
1.15 (0.85-1.54)
0.24
TC
115 (35.8%)
207 (47.4%)
0.65 (0.47-0.90)
0.004
TT
30 (9.3%)
29 (6.6%)
1.59 (0.91-2.78)
CC
79 (24.6%)
79 (18.1%)
1.18 (0.79-1.75)
Dominant
AA
144 (44.9%)
215 (49.2%)
1.00 (reference)
TT
127 (39.6%)
151 (34.5%)
1.00 (reference)
AT/TT
177 (55.1%)
222 (50.8%)
1.20 (0.90-1.61)
0.21
TC/CC
194 (60.4%)
286 (65.5%)
0.79 (0.59-1.08)
0.14
Recessive
AA/AT
291 (90.7%)
408 (93.4%)
1.00 (reference)
TT/TC
242 (75.4%)
358 (81.9%)
1.00 (reference)
TT
30 (9.3%)
29 (6.6%)
1.47 (0.86-2.50)
0.15
CC
79 (24.6%)
79 (18.1%)
1.47 (1.04-2.08)
0.03
Overdominant
AA/TT
174 (54.2%)
244 (55.8%)
1.00 (reference)
TT/CC
206 (64.2%)
230 (52.6%)
1.00 (reference)
AT
147 (45.8%)
193 (44.2%)
1.08 (0.80-1.43)
0.64
TC
115 (35.8%)
207 (47.4%)
0.61 (0.45-0.82)
0.001
Allele
A
435 (67.8)
623 (71.3)
1.18 (0.95-1.47)
0.14
T
369 (57.5)
509 (58.2)
1.03 (0.84-1.27)
0.77
T
207 (32.2)
251 (28.7)
C
273 (42.5)
365 (41.8)
corresponds to the number of individuals. Boldfaced values indicate a significant difference at the 5% level.
