Associations between Interleukin-32 Gene Polymorphisms rs12934561 and rs28372698 and Susceptibilities to Bladder Cancer and the Prognosis in Chinese Han Population
Table 4
Association between SNPs in IL-32 and patient outcome.
SNP/genotype
NMIBC
MIBC
Alive/dead,
HR (95% CI)a
Recurrence/nonrecurrence
HR (95% CI)a
Alive/dead,
HR (95% CI)a
Recurrence/nonrecurrence
HR (95% CI)a
rs28372698
AA
68/7
52/23
57/12
50/19
AT
72/6
59/19
50/19
46/23
TT
17/0
11/6
7/6
8/5
Dominant
0.66 (0.22-1.98)
0.46
0.72 (0.40-1.28)
0.26
1.83 (0.92-3.65)
0.09
1.54 (0.85-2.78)
0.16
Recessive
NA
0.98
1.57 (0.66-3.76)
0.31
2.77 (1.11-6.90)
0.028
2.06 (0.79-5.36)
0.14
Overdominant
0.86 (0.29-2.59)
0.79
0.60 (0.33-1.09)
0.09
1.22 (0.64-2.32)
0.56
1.24 (0.70-2.21)
0.46
rs12934561
TT
64/5
46/23
45/13
40/18
TC
61/3
47/17
38/13
39/12
CC
32/5
29/8
31/11
25/17
Dominant
0.92 (0.29-2.95)
0.89
0.70 (0.39-1.26)
0.23
1.24 (0.61-2.53)
0.55
0.91 (0.49-1.68)
0.76
Recessive
1.92 (0.61-6.08)
0.27
0.57 (0.27-1.24)
0.16
0.95 (0.46-1.93)
0.88
1.46 (0.80-2.68)
0.22
Overdominant
0.47 (0.13-1.76)
0.27
1.03 (0.56-1.89)
0.92
1.32 (0.66-2.67)
0.43
0.60 (0.31-1.18)
0.14
corresponds to the number of individuals. aAdjusted by age, sex, and smoking status. Boldfaced values indicate a significant difference at the 5% level.
