Development of an Autophagy Score Signature for Predicting Overall Survival in Papillary Renal Cell Carcinoma

Table 3

Univariate and multivariate Cox regression analyses of autophagy signature in predicting OS.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
6-RNA signature	2.715	2.135-3.454	<0.001	4.573	1.898-11.021	0.001
Age	1.002	0.976–1.029	0.885
Gender	1.632	0.843–3.160	0.146
Tumor type	2.849	1.041-7.798	0.042	0.081	0.007–0.912	0.042
AJCC T stage (T1-2 vs. T3-4)	5.020	2.737–9.207	<0.001	1.834	0.339–9.919	0.182
N stage	5.211	2.149–12.636	<0.001	0.975	0.161–5.911	0.004
Pathological stage (I-II vs. III-IV)	2.051	1.393–3.201	<0.001	2.154	0.073–63.570	0.004
Laterality (left vs. right)	0.760	0.403–1.431	0.395
Smoking status	0.352	0.122–1.015	0.053