Use of a Four-miRNA Panel as a Biomarker for the Diagnosis of Stomach Adenocarcinoma

Figure 3

Relative expression levels and receiver operating characteristic curve (ROC) analyses of the 8 selected miRNAs in the validation phase. This phase included 80 STAD patient serum and 80 HC serum samples. The miRNAs that were highly expressed in STAD were (g) miR-125b-5p and (m) miR-196a-5p. Their AUCs were (h) 0.675 (95% CI: 0.596 to 0.747) and (n) 0.731 (95% CI: 0.655 to 0.798), respectively. miRNAs with significantly low-expression levels were (a) miR-1-3p, (e) miR-100-5p, (i) miR-143-3p, (k) miR-149-5p, and (o) miR-224-5p. Their AUCs were (b) 0.719 (95% CI: 0.550 to 0.700) for miR-1-3p, (f) 0.704 (95% CI: 0.627 to 0.773) for miR-100-5p, (j) 0.618 (95% CI: 0.538 to 0.693) for miR-143-3p, (l) 0.661 (95% CI: 0.582 to 0.734) for miR-149-5p, and (p) 0.606 (95% CI: 0.526 to 0.683) for miR-224-5p. The expression level of miR-21-5p made no sense (). ; ; .

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