Accurate Noninvasive Assessment of Myocardial Iron Load in Advanced Heart Failure Patients

Table 3

Associations between myocardial iron load in the failing left ventricle and commonly used iron, red blood cell, and heart failure (HF) severity parameters.

(a) Associations with iron-related serum parameters

LV M-Iron

Iron

Transferrin

TSAT

TIBC

UIBC

sTfR1

FR

sTfR1/logFR

(b) Associations with red blood cell-related parameters

LV M-Iron

TIRD

RBC

Hb

Hct

MCV

MCH

MCHC

Weight

EPO

(c) Associations with HF severity-related parameters

LV M-Iron

LVESV

LVEDV

LVEF

RVD

mPWP

PVR

NT-proBNP

hsCRP

TNFα

Serum sodium

Creatinine clearance

LV M-Iron: left ventricle myocardial iron load. Iron-related serum parameters: iron: serum iron; TSAT: transferrin saturation; TIBC: total iron-binding capacity; UIBC: unsaturated iron-binding capacity; sTfR1: soluble transferrin receptor 1; FR: ferritin. Red blood cell-related parameters: TIRD: total iron dose required for iron repletion calculated using the Ganzoni formula; RBC: red blood cells; Hb: hemoglobin; Hct: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; EPO: erythropoietin. Heart failure severity-related parameters: LVESV/LVEDV: left ventricle volume end-diastolic/systolic; LVEF: left ventricle ejection fraction; RVD: right ventricle diastolic size; mPWP: mean pulmonary wedge pressure; PVR: pulmonary vascular resistance; NT-proBNP: N-terminal pro-B-type natriuretic peptide; hsCRP: high-sensitivity C-reactive protein; TNFα: Tumor Necrosis Factor-alpha.