|
| Protein | Gene | Cancer (references) | Overall deregulation | Association |
|
| Actin | | | | |
| β-Actin | | Breast cancer [9] | ↑ | Estrogen receptor α |
| F-Actin | | Breast cancer [12] | ↑ | Coronin 1c |
| Bladder Cancer [13] | ↑ | Piperlongumine |
| Liver cancer [14] | ↑ | ROCK1 |
| Glioma [15] | ↑ | RhoA/ROCK |
| Myosin | | | | |
| MYO1B | Prostate cancer [17] | ↑ | Organization of the actin cytoskeleton |
| Head and neck squamous cell carcinoma [18] | ↑ | NR |
| Melanoma [19] | ↑ | NR |
| MYO1F | Acute myeloid leukemias [21] | ↑ | Thet (11;19) (q23;p13) fusing MLL |
| MYO1A | Colorectal cancer [22] | ↓ | Actin bundle and plasma membrane |
| Myosin IIA | | Gastric cancer [30] | ↑ | cJun N-terminal kinase signaling pathway |
| Esophageal squamous cancer [31] | ↑ | Cell migration |
| Bladder cancer [32] | ↑ | NR |
| Squamous cell carcinomas [33] | ↓ | P53 |
| Myosin IIB | | Breast cancer [35] | ↑ | Ribonucleoprotein-E1 |
| Myosin IIC | | Breast cancer [35] | ↑ | Ribonucleoprotein-E1 |
| MYO5A | Colorectal cancer [23] | ↑ | Snail, Bmf |
| MYO5B | Gastric cancer [36] | ↑ | Rab11a |
| MYO5C | Prostate cancer [17] | ↑ | Actin organization and cell morphology |
| MYO6 | Lung cancer [38] | | ERK1/2 |
| Breast cancer [39] | NR |
| Hepatocellular carcinoma [40] | PRAS40, p38 |
| Ovarian cancer [41] | ↑ | NR |
| Prostate cancer [42] | ↑ | Androgen receptor |
| MYO7 | Melanoma [45] | ↑ | NR |
| MYO9B | Prostate cancer [17] | ↑ | Organization of the actin cytoskeleton |
| Lung tumor [47] | ↑ | SLIT/ROBO |
| Esophageal cancer [48] | ↑ | Non muscle myosin 2 |
| MYO10 | Breast cancer [49] | ↑ | P53 |
| Lung adenocarcinoma [50] | ↑ | NR |
| Non-small-cell lung cancer [51] | ↑ | NF-kappaB, miR-124 |
| Prostate cancer [19] | ↑ | Organization of the actin cytoskeleton |
| MYO18B | Prostate cancer [17] | ↑ | Organization of the actin cytoskeleton |
| Pleural mesothelioma [56] | ↓ | NR |
| Ovarian cancer [57] | ↑ | NR |
| Lung cancer [58] | ↑ | HOMER2 |
| Glioblastoma, melanoma, pancreatic carcinoma [59] | ↑ | NR |
| Titin | | Lung squamous cell carcinoma, lung adenocarcinoma, and colon adenocarcinoma [61] | ↑ | P53/KRAS |
| MYBPC1 | | Breast cancer [67] | ↑ | Progesterone signaling |
| Prostate cancer [69] | ↑ | NR |
| Obscurin | | Glioblastoma, melanoma, and pancreatic carcinoma [70] | ↓ | β-Catenin |
| Breast cancer, colon cancer [74] | ↓ | β-Catenin |
| α-Actinin-4 | | Colorectal cancer [86] | ↑ | LIM kinase 1 |
| Breast cancer [87] | ↑ | Estrogen receptor α |
| Ovarian cancer [88] | ↑ | 19q12-q13 |
| Ductal carcinoma of the pancreas [89] | ↑ | 19q13.1-2 |
| Salivary gland carcinoma [90] | ↑ | NR |
| Prostate cancer [91] | ↑ | NR |
| Non-small-cell lung cancer [93] | ↑ | NR |
| Gastric cancer [94] | ↑ | NF-κB |
| Cervical cancer [97] | ↑ | Snail, beta-catenin |
| Pancreatic ductal adenocarcinoma [98] | ↑ | Fascin-1 |
| Astrocytoma [99] | ↑ | NR |
| α-Actinin-1 | | Pancreatic ductal adenocarcinoma [98] | ↑ | Fascin-1 |
| Astrocytoma [99] | ↓ | NR |
| Breast cancer [100] | ↑ | E-cadherin |
| LASP1 | | Acute myeloid leukemia [102] | ↑ | t(11;17)(q23;q21) |
| LASP2 | | Non-small-cell lung cancer [104] | ↑ | Phosphorylation of FAK |
| Bladder cancer [105] | ↑ | Wnt/β-catenin signaling pathway |
| Gallbladder cancer [106] | ↑ | G2/M phase |
| Prostate cancer [107] | ↑ | NF-kappaB pathway |
| Cholangiocarcinoma [108] | ↑ | NR |
| Hepatocellular carcinoma [109] | ↑ | Vimentin |
| Cervical cancer [110] | ↑ | PI3K/Akt/mTOR |
| Colorectal cancer [111] | ↑ | Thin filaments |
| Colorectal cancer [112] | ↓ | JNK/p38 MAPK pathway |
| Desmin | | Melanoma [116] | ↑ | NR |
| Colorectal cancer [120] | ↑ | Vimentin |
| Synemin | | Ovarian cancer [121] | ↑ | NR |
| Astrocytoma [122] | ↑ | Intermediate filament |
| Breast cancer [123] | ↑ | Zyxin |
| Hepatocellular carcinoma [124] | ↑ | Intermediate filament |
| Plectin | | Pancreatic intraductal papillary mucinous neoplasm [127] | ↑ | NR |
| Lung cancer [128] | ↑ | NR |
| Colon carcinoma [129] | ↑ | Isoform-specific |
| Prostate cancer [130] | ↑ | Nyalwidhe |
| HNSCC [131] | ↑ | Erk 1/2 kinase |
| Breast cancer [132] | ↑ | Periplakin |
| Ovarian cancer [136] | ↑ | PARP |
| Nesprin-1 | | Ovarian cancer [138] | ↓ | ESR1/SYNE1 |
| Breast and colorectal cancers [73] | ↓ | NR |
| Lung cancer [139] | ↓ | Methylation |
| Glioblastoma [140] | ↓ | P53 |
| Nesprin-2 | | Ovarian cancer [147] | ↓ | Ca(2+)/calmodulin |
| Vimentin | | Prostate cancer [153] | ↑ | E-cadherin/β-catenin |
| Gastric cancer [154] | ↑ | circNHSL1 |
| Esophageal squamous cell carcinoma [155] | ↑ | NR |
| Hepatocellular carcinoma [156] | ↑ | NR |
| Colorectal carcinoma [157] | ↑ | Methylation |
| Pancreatic cancer [159] | ↑ | NR |
| Breast cancer [160] | ↑ | β-Catenin |
| Melanoma [162] | ↑ | NR |
| Glioma [163] | ↑ | Cellular density |
| Meningiomas [164] | ↑ | NR |
| Lung cancer [165] | ↑ | NF-kappaB |
|
