15-lncRNA-Based Classifier-Clinicopathologic Nomogram Improves the Prediction of Recurrence in Patients with Hepatocellular Carcinoma
Table 3
Univariable and multivariable Cox regression analysis for prediction of RFS.
Factors
Subgroup
Univariable analysis
Multivariable analysis
HR (95% CI)
HR (95% CI)
Age
1.00 (0.99-1.02)
0.673
NA
NA
Sex
Female
1
Male
0.89 (0.57-1.39)
0.621
NA
NA
Race
Asian
1
White
1.15 (0.75-1.78)
0.522
NA
NA
Black or African American
0.96 (0.34-2.70)
0.932
NA
NA
Family history
No
1
Yes
0.68 (0.42-1.09)
0.109
NA
NA
HBV
No
1
Yes
0.80 (0.51-1.28)
0.359
NA
NA
HCV
No
1
Yes
1.64 (0.98-2.64)
0.058
NA
NA
Alcohol consumption
No
1
Yes
1.04 (0.67-1.62)
0.863
NA
NA
Mutation count
1.02 (1.01-1.03)
0.007
1.02 (1.00-1.03)
0.032
Fraction genome altered
2.86 (0.97-8.42)
0.057
NA
NA
BMI
≤24
1
>24
0.57 (0.37-0.89)
0.014
0.76 (0.47-1.04)
0.084
AFP
≤20
1
1
>20
1.79 (1.14-2.82)
0.012
1.82 (1.14-2.90)
0.012
Platelet
≤200
1
>200
1.26 (0.79-2.00)
0.328
NA
NA
Albumin
≤4.0
1
>4.0
0.96 (0.60-1.52)
0.855
NA
NA
Creatinine
<1.1
1
≥1.1
0.81 (0.47-1.40)
0.445
NA
NA
Liver cirrhosis
No
1
Yes
2.17 (1.14-4.11)
0.018
1.56 (0.87-2.12)
0.122
Histological grade
G1-G2
1
G3-G4
1.07 (0.68-1.67)
0.772
NA
NA
T stage
T1-T2
1
T3-T4
3.12 (1.98-4.92)
≤0.001
2.50 (1.54-4.05)
≤0.001
TNM stage
Stage I-II
1
Stage III-IV
2.71 (1.71-4.30)
≤0.001
1.12 (0.47-2.69)
0.801
ECOG
0
1
>0
2.41 (1.54-3.77)
≤0.001
2.00 (1.23-3.23)
0.005
lncRNA classifier
1.13 (1.09-1.18)
≤0.001
1.13 (1.09-1.18)
≤0.001
Abbreviations: HR: hazard ratio; CI: confidence intervals; NA: not available. These variables were eliminated in the multivariate Cox regression model, so the HR and values were not available. .
