Selected Metal Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases as Potential Biomarkers for Tubulointerstitial Fibrosis in Children with Unilateral Hydronephrosis

Table 3

The results of urinary excretions of MMPs and TIMPs in study groups A, B, and C and control groups.

Variable	Group		Median	Range	Statistical analysis
MMP-1/Cr (pg/mg)	A	25	171.2	89.5-1125.1	A vs. controls
	B	11	170.2	93.4-1521.5	B vs. controls
	C	9	169.8	47.6-765.4	C vs. controls
	Controls	21	164.4	86.9-1488.8
MMP-2/Cr (pg/mg)	A	25	401.2	120.2-2310.0	A vs. controls
	B	11	323.1	87.9-628.3	B vs. controls
	C	9	315.8	121.1-399.8	C vs. controls
	Controls	21	305.9	129.3-979.3
MMP-9/Cr (pg/mg)	A	25			A vs. controls
	B	11			B vs. controls
	C	9			C vs. controls
	Controls	21
TIMP-1/Cr (pg/mg)	A	25			A vs. controls
	B	11			B vs. controls
	C	9			C vs. controls
	Controls	21
TIMP-2/Cr (pg/mg)	A	25			A vs. controls
	B	11			B vs. controls
	C	9			C vs. controls
	Controls	21
MMP-1/TIMP-1	A	25	0.38	0.11-1.0	A vs. controls
	B	11	0.32	0.11-0.54	B vs. controls
	C	9	0.5	0.30-0.71	C vs. controls
	Controls	21	0.44	0.11-0.66
MMP-2/TIMP-1	A	25	0.1	0.04-1.0	A vs. controls
	B	11	0.7	0.11-2.4	B vs. controls
	C	9	0.8	0.11-0.92	C vs. controls
	Controls	21	0.9	0.20-4.2
MMP-9/TIMP-1	A	25	1.2	0.03-1.51	A vs. controls
	B	11	1.9	0.1-6.4	B vs. controls
	C	9	0.9	0.1-1.7	C vs. controls
	Controls	21	1.2	0.35-16.2
MMP-1/TIMP-2	A	25	0.2	0.1-0.3	A vs. controls
	B	11	0.12	0.03-0.4	B vs. controls
	C	9	0.1	0.03-0.23	C vs. controls
	Controls	21	0.1	0.02-0.2
MMP-2/TIMP-2	A	25	0.05	0.02-0.28	A vs. controls
	B	11	0.11	0.01-0.3	B vs. controls
	C	9	0.09	0.02-0.41	C vs. controls
	Controls	21	0.1	0.02-0.31
MMP-9/TIMP-2	A	25	0.18	0.06-0.28	A vs. controls
	B	11	0.2	0.09-0.28	B vs. controls
	C	9	0.09	0.03-0.2	C vs. controls
	Controls	21	0.1	0.04-0.32

Cr: creatinine.