Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy
Table 3
The frequency distribution of MMP1, MMP9, COL1A1, and COL1A2 variants in the studied patients.
Polymorphism
Control group ()
AsAA ()
TAD ()
(%)
(%)
(%)
rs1799750 MMP1
1G1G
23 (37.7)
14 (29.8)
15 (30.6)
1G2G
27 (44.3)
24 (51.1)
29 (59.2)
0.683
0.256
0.448
2G2G
11 (18.0)
9 (19.1)
5 (10.2)
1G/2G
73/49 (59.8/40.2)
52/42 (55.3/44.7)
59/39 (60.2/39.8)
0.506
0.956
0.494
rs3918242 MMP9
CC
45 (73.8)
37 (78.7)
37 (75.5)
CT
13 (21.3)
10 (21.3)
11 (22.5)
0.302
0.724
0.605
TT
3 (4.9)
0 (0.0)
1 (2.0)
C/T
103/19 (84.4/15.6)
84/10 (89.4/10.6)
85/13 (86.7/13.3)
0.292
0.630
0.576
rs1800012 COL1A1
GG
38 (62.3)
31 (66.0)
34 (69.4)
GT
21 (34.4)
14 (29.8)
13 (26.5)
0.861
0.669
0.936
TT
2 (3.3)
2 (4.2)
2 (4.1)
G/T
97/25 (79.5/20.5)
76/18 (80.8/19.2)
81/17 (82.6/17.4)
0.807
0.556
0.747
rs42524 COL1A2
CC
35 (57.4)
18 (38.3)
25 (51.0)
CG
22 (36.1)
25 (53.2)
22 (44.9)
0.143
0.596
0.376
GG
4 (6.6)
4 (8.5)
2 (4.1)
C/G
92/30 (75.4/24.6)
61/33 (64.9/35.1)
72/26 (73.5/26.5)
0.092
0.743
0.198
Chi2 test for genotypes and alleles; AsAA: ascending aortic aneurysm; TAD: thoracic aortic dissection; : control subjects versus AAA patients; : control subjects versus TAD patients; : AAA patients versus AAA patients.
