Genetic Polymorphisms of MMP1, MMP9, COL1A1, and COL1A2 in Polish Patients with Thoracic Aortopathy

Table 6

Multivariate logistic regression analysis for the prediction of large aortic valve regurgitation () in patients with aortopathy.

Independent variables	OR (95% CI)	value
MMP1 (at least one 2G allele)	0.03 (0.01–0.24)	0.001
MMP9 (number of T alleles)	0.11 (0.03–0.49)	0.003
COL1A1 (number of T alleles)	0.28 (0.10–0.78)	0.013
AsAA	6.25 (1.31–33.3)	0.019
Maximal diameter of aorta (mm)	1.09 (1.01–1.19)	0.033
BAV	0.26 (0.06–1.12)	0.066
DM	0.08 (0.01–0.83)	0.032

OR: odds ratio; (95% CI): 95% confidence interval; AsAA: ascending aortic aneurysm; BAV: bicuspid aortic valve; DM: diabetes mellitus.