Perineural Invasion Should Be Regarded as an Intermediate-Risk Factor for Recurrence in Surgically Treated Cervical Cancer: A Propensity Score Matching Study
Table 1
Patient characteristics.
Patient characteristics
Before PSM
After PSM
PNI (+),
PNI (-),
PNI (+),
PNI (-),
Mean age (yr)
0.03
0.05
Average tumor size (cm)
0.01
0.93
Pathological type
Squamous carcinoma
116 (71.6%)
1462 (87.3%)
0.02
116 (71.6%)
118 (72.8%)
0.89
Adenocarcinoma
31 (19.1%)
153 (9.1%)
31 (19.1%)
28 (17.3%)
Adenosquamous carcinoma
15 (9.3%)
59 (3.5%)
15 (9.3%)
16 (9.9%)
Tumor differentiation
Well
8 (4.9%)
235 (14.0%)
0.01
8 (4.9%)
6 (3.7%)
0.93
Moderate
63 (38.9%)
724 (43.3%)
63 (38.9%)
63 (38.9%)
Poor
91 (56.2%)
715 (42.7%)
91 (56.2%)
93 (57.4%)
FIGO stage
IA2
0
63 (3.8%)
0.01
0
0
0.96
IB1
41 (25.3%)
752 (44.9%)
41 (25.3%)
38 (23.5%)
IB2
13 (8.0%)
209 (12.5%)
13 (8.0%)
14 (8.6%)
IIA1
59 (36.4%)
204 (12.2%)
59 (36.4%)
60 (37.0%)
IIA2
26 (16.1%)
136 (8.1%)
26 (16.0%)
27 (16.7%)
IIB
23 (14.2%)
98 (5.9%)
23 (14.2%)
23 (14.2%)
Primary therapy
Radical surgery
111 (68.5%)
1284 (76.7%)
0.01
111 (68.5%)
98 (60.5%)
0.12
NACT
51 (31.5%)
390 (23.3%)
51 (31.5%)
64 (39.5%)
NACT courses
2.3
2
0.36
2.3
2.2
0.78
Response to NACT
pCR
0
41 (10.5%)
0.01
0
6 (9.4%)
0.01
CR
0
52 (13.3%)
0
7 (10.9%)
PR
39 (76.5%)
245 (62.8%)
39 (76.5%)
42 (65.6%)
SD
11 (21.6%)
40 (10.3%)
11 (21.6%)
9 (14.1%)
PD
1 (2.0%)
12 (3.1%)
1 (2.0%)
0
Surgical approach
Minimally invasive surgery
12 (7.4%)
136 (8.1%)
0.46
12 (7.4%)
20 (12.3%)
0.14
Laparotomy
150 (92.6%)
1538 (91.9%)
150 (92.6%)
142 (87.7%)
PNI: perineural invasion; FIGO: International Federation of Gynecology and Obstetrics; NACT: neoadjuvant chemotherapy; pCR: pathological complete remission; CR: complete remission; PR: partial remission; SD: stable disease; PD: progress disease.
