Characterization of Cancer Stem Cell Characteristics and Development of a Prognostic Stemness Index Cell-Related Signature in Oral Squamous Cell Carcinoma

Figure 3

Establishment of a prognosis-associated mRNAsi-related signature for OSCC. (a) Tenfold cross-verification for tuning parameter selection in the LASSO regression model. Two dotted vertical lines were plotted for the optimal values through the minimum criteria. (b) LASSO coefficient profiles of selected mRNAsi-related signatures. (c) Visualization of risk scores of OSCC patients. The median mRNAsi score was utilized as the cutoff value (dotted vertical line). All patients were clustered into high- and low-risk score groups. Red dots: high-risk specimens and green dots: low-risk specimens. (d) Visualization of dead and alive OSCC patients with high- and low-risk score. Red dots represented dead status, and green dots represented alive status. (e) Survival analyses of OSCC subjects with high- and low-risk scores with Kaplan-Meier curves. (f) Heat map of the expression of the mRNAsi-related signatures in specimens with high- and low-risk scores. Red represented upregulation and purple represented downregulation.

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