Research Article
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa
Figure 5
Inhibition of PKM2 reduces apoptosis induced by blue light exposure in 661W cells. (a, b) Dose-dependent effects of shikonin on apoptosis, determined by calcein-AM/PI double staining, of 661W cells at 48 h after light exposure. (c, d) Western blotting showing the effects of shikonin on BCL2 and BAX expression levels in 661W cells after light exposure. Notes: data from three separate experiments () were averaged and analyzed by one-way ANOVA with post hoc LSD correction. ns: not significant. and versus the relevant control groups (0 μM shikonin).
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