Genetic Polymorphisms of IFNG, IFNGR1, and Androgen Receptor and Chronic Prostatitis/Chronic Pelvic Pain Syndrome in a Chinese Han Population
Table 4
Genetic models of SNPs and NIH-CPSI score in patients with CP/CPPS by using logistic regression.
SNP
Model
Genotype
Crude mean difference (95% CI)
AIC
BIC
Adjusted mean difference (95% CI)a
AIC
BIC
IFNG
rs2069718
Codominant model
GA/AA
1.62 (-1.08-4.31)
0.49
769.2
780.2
1.66 (-1.04-4.36)
0.48
770.3
784.1
GG/AA
-0.59 (-7.68-6.51)
-0.16 (-7.32-6.99)
Log-additive model
-
0.94 (-1.29-3.17)
0.41
768
776.3
1.05 (-1.19-3.29)
0.36
768.9
780
rs1861493
Codominant model
GA/AA
-1.21 (-3.64-1.22)
0.57
769.5
780.6
-1.29 (-3.72-1.15)
0.56
770.6
784.4
GG/AA
-1.36 (-4.72-2.01)
-1.16 (-4.55-2.23)
Log-additive model
-
-0.80 (-2.39-0.80)
0.33
767.7
776
-0.74 (-2.34-0.85)
0.36
768.9
780
IFNGR1
rs10457655
Codominant model
GA/GG
0.98 (-1.71-3.67)
0.1
765.9
777
0.99 (-1.72-3.69)
0.13
767.6
781.5
AA/GG
9.10 (0.58-17.62)
8.62 (-0.09-17.34)
Log-additive model
-
1.95 (-0.41-4.30)
0.11
766
774.3
1.86 (-0.51-4.23)
0.13
767.4
778.4
rs35860242
Codominant model
CT/CC
-0.81 (-4.28-2.65)
0.87
770.4
781.4
-1.05 (-4.54-2.44)
0.77
771.2
785.1
TT/CC
-1.05 (-8.17-6.06)
-1.67 (-8.88-5.54)
Log-additive model
-
-0.67 (-3.22-1.87)
0.6
768.4
776.7
-0.95 (-3.54-1.65)
0.48
769.3
780.3
rs3799488
Codominant model
CT/TT
-0.62 (-2.98-1.73)
0.83
770.3
781.3
-0.48 (-2.86-1.90)
0.88
771.5
785.4
CC/TT
0.54 (-4.29-5.36)
0.54 (-4.29-5.37)
Log-additive model
-
-0.19 (-2.03-1.65)
0.84
768.6
776.9
-0.11 (-1.96-1.73)
0.9
769.8
780.8
rs7749390
Codominant model
GA/GG
0.99 (-1.53-3.51)
0.72
770
781
1.07 (-1.46-3.60)
0.7
771
784.9
AA/GG
0.21 (-3.02-3.44)
0.36 (-2.89-3.61)
Log-additive model
-
0.23 (-1.35-1.81)
0.78
768.6
776.9
0.31 (-1.28-1.90)
0.71
769.6
780.7
rs9376267
Codominant model
CT/CC
-1.21 (-3.74-1.32)
0.56
760.9
771.9
-1.16 (-3.70-1.37)
0.54
762.2
776
TT/CC
-1.61 (-5.03-1.81)
-1.74 (-5.18-1.69)
Log-additive model
-
-0.87 (-2.53-0.79)
0.3
759
767.3
-0.92 (-2.59-0.74)
0.28
760.2
771.3
rs9376268
Codominant model
GA/GG
-1.28 (-3.74-1.18)
0.54
760.8
771.9
-1.27 (-3.73-1.19)
0.52
762.1
775.9
AA/GG
-1.46 (-4.95-2.02)
-1.66 (-5.19-1.86)
Log-additive model
-
-0.85 (-2.51-0.81)
0.32
759
767.3
-0.93 (-2.60-0.74)
0.28
760.2
771.3
AR
rs138464995
TT/CC
1.81 (-3.14-6.76)
0.47
697.9
706
1.65 (-3.35-6.66)
0.52
699.6
710.4
rs142203174
CC/AA
-1.50 (-5.18-2.18)
0.43
768
776.3
-1.26 (-4.99-2.46)
0.51
769.3
780.4
rs192195540
CC/GG
0.97 (-1.87-3.80)
0.51
759.6
767.9
0.92 (-1.92-3.76)
0.53
761
772.1
rs139374285
TT/CC
-1.53 (-7.06-4.00)
0.59
768.3
776.7
-1.56 (-7.09-3.97)
0.58
769.5
780.5
rs72627670
TT/CC
0.02 (-3.21-3.25)
0.99
760.1
768.4
0.07 (-3.17-3.31)
0.97
761.4
772.5
rs144488434
TT/CC
3.69 (-1.80-9.19)
0.19
766.9
775.2
3.55 (-1.96-9.06)
0.21
768.2
779.2
rs143099096
AA/CC
2.57 (-3.57-8.72)
0.41
768
776.3
2.36 (-3.81-8.53)
0.45
769.2
780.3
rs78445514
CC/TT
-0.50 (-3.53-2.53)
0.75
768.5
776.8
-0.74 (-3.80-2.33)
0.64
769.5
780.6
rs141340859
CC/TT
1.98 (-2.17-6.13)
0.35
759.2
767.5
2.02 (-2.14-6.17)
0.34
760.5
771.6
rs5965429
GG/AA
1.51 (-0.98-4.01)
0.24
744.6
752.9
1.51 (-0.99-4.01)
0.24
745.9
756.9
AIC: Akaike’s Information Criterion; BIC: Bayesian Information Criterion; CP/CPPS, chronic prostatitis/chronic pelvic pain syndrome; MD: mean difference; NIH-CPSI: National Institutes of Health Chronic Prostatitis Symptom Index; OR: odds ratio; SNPs: single nucleotide polymorphisms. aAdjusted by age.
