The Prognostic Value of the Albumin to Gamma-Glutamyltransferase Ratio in Patients with Hepatocellular Carcinoma Undergoing Radiofrequency Ablation

Table 3

Univariate and multivariate analyses for overall survival in the training cohort and validation cohort.

Variable	Training cohort			Validation cohort
	Univariate analysis	Multivariate analysis	value	Univariate analysis	Multivariate analysis	value
	value	HR (95% CI)		value	HR (95% CI)
Age (>65)	0.298			0.781
Gender (female/male)	0.370			0.451
HBV infection (presence)	0.875			0.389
HCV infection (presence)	0.274			0.253
Liver cirrhosis (no/yes)	0.234			0.631
AGR stage	0.012	2.295 (1.248-4.221)	0.008	0.024	3.327 (1.349-8.206)	0.009
AKP (U/L) (>135)	0.031	3.299 (1.458-7.467)	0.004	0.039	3.409 (1.317-8.825)	0.012
CP grade (A vs. B)	0.024			0.245
Tumor number (single, multiple)	0.485			0.466
Tumor size (cm) (≤3, 3–5)	0.044	2.002 (1.108-3.974)	0.047	0.021	2.090 (1.223-3.573)	0.007
TB (μmol/L) (≥34)	0.952			0.441
ALT (U/L) (>40)	0.364			0.682
AFP (ng/mL) (>400)	0.624			0.570
ALBI grade (1/2/3)	0.017			0.111
AJCC TNM-8 (Ia, Ib, II)	0.945			0.307

Abbreviations: HR: hazard ratio; HBV: hepatitis B virus; HCV: hepatitis C virus; AGR: albumin to gamma-glutamyltransferase ratio; AKP: alkaline phosphatase; CP grade: Child-Pugh grade; TB: total bilirubin; ALT: alanine aminotransferase; AFP: alfa-fetoprotein; ALBI grade: albumin-bilirubin grade; AJCC TNM-8: the 8th edition of American Joint Committee on Cancer TNM staging system. Statistically significant.