Cysteine-Rich Intestinal Protein 1 Served as an Epithelial Ovarian Cancer Marker via Promoting Wnt/β-Catenin-Mediated EMT and Tumour Metastasis

Figure 1

Genetic screening and bioinformatics analysis of cysteine-rich intestinal protein 1 (CRIP1). (a) 2,613 genes were significantly upregulated in ovarian cancer tissues using the online differential gene expression analysis tool, and 1,378 survival significant genes were obtained through survival analysis; 358 genes were excluded for being published on PubMed. After taking the intersection of the three, 51 target genes were obtained in the end. (b) After ranking the 51 target genes by -log₁₀ ( value), the top five genes were obtained, and then, the survival and hazard ratio (HR) analysis of these genes was conducted on the survival analysis website. The survival plots of the top five target genes suggested that only high expression of CRIP1 and PLEK2 could affect prognosis (). (c) Box plot showing the significantly upregulated expression of CRIP1 in ovarian cancer tissues (left, red; ) compared with nonneoplastic tissues (right, black; ) (). (d) Violin plot showing a correlation between increased CRIP1 expression and increased pathological grade in ovarian cancer ().

(a)

(b)

(c)

(d)