N-Acetylcysteine Slows Down Cardiac Pathological Remodeling by Inhibiting Cardiac Fibroblast Proliferation and Collagen Synthesis

Figure 1

NAC improves the damaged heart structure of rats after aortic constriction. (a) Echocardiography detected the LVEDd of rats. (b) Echocardiography detected the LVESd of rats. (c) Echocardiography detected the LVEF% of rats. (d) Echocardiography detected the LVFS% of rats. (e) Ratio of Lvw/BW. (f) Ratio of Lvw/TL. (g) Masson staining and positive area analysis (magnification: 200x). (h) WB detected the Collagen I expression and gray value analysis. GAPDH was used as an internal control. (i) qRT-PCR detected the Collagen I expression. “” indicates the statistical difference from the control group, ; “#” indicates the statistical difference from the aortic constriction group, . LVEDd: left ventricular end-diastolic diameter; LVESd: left ventricular end-systolic diameter; LVEF: left ventricular ejection fraction; LVFS: left ventricular fractional shortening; Lvw: left ventricular weight; BW: body weight; TL: tibial length.

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