Differences in Immunological Landscape between EGFR-Mutated and Wild-Type Lung Adenocarcinoma

Table 2

		EGFR mutant					Wild type
		Univariate	value	HR	Multivariate	value	Univariate	value	HR	Multivariate
Clinicopathologic features	HR	95% CI			95% CI		HR95% CI			95% CIP value
vs <66	1.305	0.988 to 2.987	0.030	1.169	1.112 to 1.877	0.009	1.1430.329 to 2.619	0.811
Male vs female	0.927	0.539 to 2.101	0.893				1.6240.510 to 4.364	0.351
Smoking vs no smoking	1.323	0.321 to 3.257	0.610				1.1120.211 to 3.401	0.941
T stage: T1 vs T2–3	0.391	0.145 to 0.840	0.021	0.531	0.126 to 1.216	0.323	0.7180.208 to 1.204	0.513
N stage: N0 vs N1–2	0.801	0.354 to 2.135	0.611				0.1640.043 to 0.491	0.001	0.312	0.089 to 1.1210.069
Pathological stage: I vs II–IIIA	0.331	0.164 to 0.805	0.022	0.421	0.170 to 1.214	0.132	0.2270.079 to 0.799	0.014	0.316	0.075 to 2.1990.314
Vascular infiltration: positive vs negative	3.788	1.573 to 15.201	0.001	0.601	0.283 to 1.729	0.301	3.2011.609 to 10.821	0.004	0.716	0.266 to 2.2150.715
Pleural infiltration: positive vs negative	3.804	1.277to 7.112	0.016	0.721	0.219 to 2.228	0.739	0.8860.367 to 2.112	0.801
Surgical method: wedge vs total resection	0.704	0.195 to 2.140	0.622				2.7210.518 to 6.412	0.301
CD3: low vs high	1.311	0.538 to 2.106	0.434				0.7320.236 to 2.112	0.615
CD4: low vs high	1.201	0.501 to 2.135	0.501				1.1330.368 to 2.160	0.829
CD8: low vs high	0.820	0.417 to 2.007	0.277				1.2440.442 to 3.223	0.544
Foxp3: low vs high	0.713	0.289 to 0.912	0.022	0.711	0.381 to 1.101	0.017	2.1360.711 to 4.111	0.201
LAG3: low vs high	2.014	0.834 to 4.324	0.112				4.2421.609 to 6.757	0.126
PD-L1: positive vs negative	1.114	0.492 to 2.303	0.791				0.6500.213 to 2.406	0.611
PD-1: low vs high	0.335	0.654 to 1.142	0.031	0.402	0.413 to 1.212	0.102	0.6990.211 to 2.112	0.664