Diagnostic, Prognostic, Predictive, and Monitoring Role of Neutrophil CD11b and Monocyte CD14 in Neonatal Sepsis

Table 5

Diagnostic performance of the studied parameters and their combinations arranged in ascending order in terms of their efficacy values.

Parameter	Cutoff value	TN	FP	TP	FN	% specificity	% sensitivity	%NPV	%PPV	%eff.
Hb	8.8	10	87	81	4	10.3	95.3	71.4	48.2	50.0
PLT	524	91	3	6	78	96.8	7.1	53.8	66.7	54.5
mCD14%	93%	87	4	8	72	95.6	10.0	54.7	66.7	55.6
TLC	18.6	83	14	23	62	85.6	27.1	57.2	62.2	58.2
AMC	1.95	73	17	22	49	81.1	31.0	59.8	56.4	59.0
ALC	8.8	88	2	9	61	97.8	12.9	59.1	81.8	60.6
nCD11b MFI	7.73	98	2	16	66	98.0	19.5	59.8	88.9	62.6
ANC	4.4	43	40	59	20	51.8	74.7	68.3	59.6	63.0
mCD14 MFI	9.36	64	25	43	14	71.9	75.4	82.1	63.2	73.3
nCD11b%	99%	94	6	41	41	94.0	50.0	69.6	87.2	74.2
hs-CRP	6	94	6	59	25	94.0	70.2	79.0	90.8	83.2
nCD11b% & hs-CRP	nCD11b% 95.6 & CRP at 6 mg/L	96	4	79	0	96.0	100.0	100.0	95.2	97.8

ANC: absolute neutrophil count (×10⁹/L); Hb: hemoglobin (g/dL); hs-CRP: highly sensitive CRP (mg/L); nCD11b%: neutrophil CD11b%; nCD11b MFI: nCD11b mean fluorescence intensity; mCD14%: monocyte CD14%; mCD14 MFI: mCD14 mean fluorescence intensity; eff.: efficacy; NPV: negative predictive value; PPV: positive predicted value; TP: true positive; TN: true negative; FP: false positive; FN: false negative.