MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure

Figure 1

Expressions of miR-181b were downregulated in serum from human subjects with HF and correlated with established biomarkers of HF. (a) mMiR-181b, miR-21, and miR-155 expressions were detected by qPCR in serum from ICM-induced HF patients (), DCM-induced HF patients (), and healthy individuals (). Data are shown as . compared with the control group. (b) Diagnostic performance of the relative abundances of miR-181b. AUC-ROC differentiates DCM-induced HF patients from normal subjects (miR-181b, 0.970) and differentiates ICM-induced HF patients from normal subjects (miR-181b, 0.962). (c, d) Correlation between miR-181b level and hsCRP level in the serum samples of HF patients. Pearson’s correlation coefficients: (, DCM group) and (, ICM group).

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