MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure

<div>miR-181b expression was downregulated in the early stage of HF. (a, b) Real-time PCR analysis of miR-181b expression in rat heart tissue administered by ISO or saline vehicle for one month or three months, respectively. (c–e) Western blot analysis of TNF-<i>α</i>, IL-1, and IL-6 in rat heart tissue administered by ISO for one month. (f–h) Western blot analysis of TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 in rat heart tissue administered by ISO for three months. (i, j) qPCR analysis of TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 mRNA levels in rat heart tissue. Rat heart tissue was administered as indicated in (a) and (b). 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Disease Markers

fig3

Figure 3

Figure 3: MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure 