Identification of Epithelial-Mesenchymal Transition- (EMT-) Related LncRNA for Prognostic Prediction and Risk Stratification in Esophageal Squamous Cell Carcinoma

Table 1

Uni- and multivariate regression analysis in ESCC patients.

Variables	Univariate COX regression				Multivariate COX regression
	Training cohort		Validation cohort		Training cohort		Validation cohort
	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value	HR (95% CI)	value
Risk stratification
Low risk	Reference		Reference		Reference		Reference
High risk	3.70 (2.05, 6.66)	< 0.001	2.54 (1.27, 5.07)	0.009	3.89 (2.13, 7.11)	< 0.001	2.73 (1.29, 5.78)	0.008
Age, years
≤ 60	Reference		Reference		Reference		Reference
>60	1.58 (1.00, 2.50)	0.051	1.97 (0.98, 3.97)	0.057	1.77 (1.10, 2.85)	0.018	1.95 (0.95, 4.00)	0.067
Gender
Female	Reference		Reference
Male	0.83 (0.47, 1.46)	0.513	0.71 (0.31, 1.64)	0.424
T
T1-2	Reference		Reference
T3-4	0.96 (0.57, 1.64)	0.891	1.55 (0.60, 4.01)	0.369
N
N0	Reference		Reference		Reference		Reference
N1-3	2.16 (1.32, 3.54)	0.002	2.02 (0.99, 4.12)	0.053	1.11 (0.57, 2.17)	0.758	2.47 (0.66, 9.24)	0.179
TNM stage
I/II	Reference		Reference		Reference		Reference
III/IV	2.16 (1.32, 3.54)	0.002	2.01 (1.01, 4.01)	0.046	1.91 (0.99, 3.71)	0.055	0.80 (0.22, 2.99)	0.742
Tumor grade
Well	Reference		Reference
Moderate/poor	1.00 (0.56, 1.80)	0.989	2.04 (0.62, 6.70)	0.239

CI: confidence interval; HR: hazard ratio; N: lymph node metastasis; T: tumor invasion depth.