Association of Preoperative Serum Levels of CEA and CA15-3 with Molecular Subtypes of Breast Cancer

Table 6

Multiple logistic regression analysis of the association of clinicopathological characteristics with serum CEA, CA15-3, and CA125 levels.

Characteristic	OR	CI	value
Model 1 CEA
Age (years)
≥50 vs. <50	4.319	2.040-9.143	0.0001
Tumor size (cm)
≥2 vs. <2	2.364	1.185-4.715	0.0146
Node status
N1 vs. N0	1.770	0.918-3.413	0.0885
Molecular type
Luminal A vs. Her2+	0.679	0.273-1.689	0.4056
Luminal B1 vs. Her2+	0.386	0.163-0.918	0.0313
Luminal B2 vs. Her2+	0.933	0.365-2.382	0.8840
Triple-negative vs. Her2+	0.294	0.078-1.110	0.0710
Model 2 CEA
Age (years)
≥50 vs. <50	4.299	2.036-9.079	0.0001
Tumor size (cm)
≥2 vs. <2	2.262	1.141-4.482	0.0193
Node status
N1 vs. N0	1.749	0.910-3.359	0.0934
Her2
Positive vs. negative	2.156	1.169-3.979	0.0139
Model 3 CA15-3
Histologic grade
Grade 2 vs. Grade 1	1.717	0.213-13.862	0.6120
Grade 3 vs. Grade 1	2.209	0.228-18.062	0.5260
Tumor size (cm)
≥2 vs. <2	3.019	1.538-5.926	0.0013
Node status
N1 vs. N0	2.633	1.387-5.001	0.0031
Molecular type
Luminal A vs. luminal B2	0.457	0.173-1.203	0.1127
Luminal B1 vs. luminal B2	0.349	0.154-0.791	0.0117
Her2+ vs. luminal B2	0.478	0.170-1.346	0.1620
Triple-negative vs. luminal B2	1.293	0.536-3.119	0.5676
Model 4 CA15-3
Histologic grade
Grade 2 vs. Grade 1	1.765	0.229-13.586	0.5851
Grade 3 vs. Grade 1	2.244	0.271-18.593	0.4536
Tumor size (cm)
≥2 vs. <2	2.865	1.464-5.608	0.0021
Node status
N1 vs. N0	2.720	1.440-5.140	0.0020
ER
Positive vs. negative	0.607	0.242-1.523	0.2874
PR
Positive vs. negative	0.794	0.327-1.924	0.6088
Model 5 CA125
Tumor size (cm)
≥2 vs. <2	1.550	0.863-2.782	0.1423
Node status
N1 vs. N0	1.903	1.070-3.386	0.0286
PR
Positive vs. negative	0.567	0.323-0.996	0.0486

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