Autoantibodies against p53, MMP-7, and Hsp70 as Potential Biomarkers for Detection of Nonmelanoma Skin Cancers
Table 2
Diagnostic values for the individual autoantibodies and the autoantibody panel in NMSC.
AUC
SEN
SPE
PPV
NPV
PLR
NLR
All stages of NMSC
p53 autoantibody
0.799 (0.739-0.859)
48.5%/40.6%
90.2%/95.0%
83.1%/89.2%
63.8%/61.7%
4.95/8.29
0.57/0.63
MMP-7 autoantibody
0.621 (0.543-0.699)
34.7%/31.7%
91.2%/95.0%
79.6%/86.5%
58.5%/58.4%
3.94/6.47
0.72/0.72
Hsp70 autoantibody
0.719 (0.649-0.789)
31.7%/29.7%
93.1%/95.0%
82.0%/85.7%
57.9%/57.7%
4.59/6.06
0.73/0.74
The autoantibody panel
0.841 (0.788-0.894)
60.4%/51.5%
91.2%/95.0%
87.2%/91.2%
69.9%/66.4%
6.86/10.51
0.43/0.51
Early-stage of NMSC
p53 autoantibody
0.819 (0.754-0.885)
49.3%/43.5%
90.2%/95.0%
77.3%/85.8%
72.4%/70.3%
5.03/8.88
0.56/0.59
MMP-7 autoantibody
0.627 (0.536-0.718)
37.7%/33.3%
91.2%/95.0%
74.4%/82.2%
68.4%/67.8%
4.28/6.80
0.68/0.70
Hsp70 autoantibody
0.746 (0.673-0.820)
31.9%/30.4%
93.1%/95.0%
75.8%/80.8%
66.9%/66.8%
4.62/6.20
0.73/0.73
The autoantibody panel
0.851 (0.793-0.908)
59.4%/52.2%
91.2%/95.0%
82.1%/87.8%
76.8%/74.6%
6.75/10.65
0.45/0.50
Skin squamous cell carcinoma
p53 autoantibody
0.790 (0.719-0.860)
47.8%/38.8%
90.2%/95.0%
76.2%/83.8%
72.5%/70.3%
4.88/7.92
0.58/0.64
MMP-7 autoantibody
0.616 (0.524-0.708)
34.3%/32.8%
91.2%/95.0%
71.8%/81.4%
67.9%/68.3%
3.90/6.69
0.72/0.71
Hsp70 autoantibody
0.697 (0.616-0.777)
28.4%/25.4%
93.1%/95.0%
73.0%/77.3%
66.5%/66.0%
4.12/5.18
0.77/0.78
The autoantibody panel
0.826 (0.761-0.891)
56.7%/49.3%
91.2%/95.0%
80.9%/86.8%
76.3%/74.1%
6.44/10.06
0.48/0.53
Skin basal cell carcinoma
p53 autoantibody
0.818 (0.736-0.900)
50.0%/44.1%
90.2%/95.0%
63.0%/85.5%
84.4%/72.2%
5.10/9.00
0.55/0.59
MMP-7 autoantibody
0.631 (0.509-0.753)
35.3%/29.4%
91.2%/95.0%
57.2%/79.7%
80.9%/67.3%
4.01/6.00
0.71/0.74
Hsp70 autoantibody
0.763 (0.672-0.854)
38.2%/38.2%
93.1%/95.0%
64.9%/83.6%
81.9%/70.1%
5.54/7.80
0.66/0.65
The autoantibody panel
0.870 (0.803-0.937)
67.6%/55.9%
91.2%/95.0%
71.9%/88.2%
89.4%/76.7%
7.68/11.41
0.35/0.46
Note: data after “/” were obtained at a specificity of 95.0%. NMSC: nonmelanoma skin cancer; AUC: the area under the receiver operating characteristic curve; SEN: sensitivity; SPE: specificity; PPV: positive predictive value; NPV: negative predictive value; PLR: positive likelihood ratio; NLR: negative likelihood ratio.
