Whole Blood Transcriptome Analysis Reveals the Correlation between Specific Immune Cells and Septicemic Melioidosis

Figure 4

Further confirmation of the correlation between selected immune cell types and the onset of septicemic melioidosis. (a) Heatmap depicting correlation among selected immune cell types and several clinical features in the patients with melioidosis, with absolute value > 0.5 highlighted with color round marks. (b) Receiver-operating characteristic curves depicting the combinations of selected immune cell types between patients with melioidosis and healthy control. The curves with at least one immune cell type’s value less than 0.05 were allowed to be plotted. AUC (area under the curve), specificity, and sensitivity were shown in the following brackets. M0 macrophages (0.91, 1.00, 0.65); naive CD4+ cells (0.91, 0.88, 0.88); naive CD4+ cells + M0 macrophages (0.96, 1.00, 0.9); neutrophils (0.94, 0.88, 0.95); resting CD4 memory T cells (0.94, 1.00, 0.78); resting CD4 memory T cells + M0 macrophages (0.97, 0.88, 0.98); naive CD4+ cells + resting CD4 memory T cells (0.98, 1.00, 0.88); CD8+ T cells + M0 macrophages + neutrophils (0.98, 1.00, 0.98); resting CD4 memory T cells + neutrophils (0.97, 0.88, 1.00); CD8+ T cells + M0 macrophages (0.98, 1.00, 0.98); CD8+ T cells (0.98, 1.00, 0.98); CD8+ T cells + neutrophils (0.98, 1.00, 0.97); naive CD4+ cells + neutrophils (0.99, 1.00, 0.93).

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