E2F1-Induced lncRNA BAIAP2-AS1 Overexpression Contributes to the Malignant Progression of Hepatocellular Carcinoma via miR-361-3p/SOX4 Axis

Figure 6

SOX4 is directly targeted by miR-361-3p. (a) Sequence alignment of miR-361-3p and 3UTR of SOX4 using StarBase 2.0. (b) The overexpression of SOX4 in HCC specimens compared to normal tissues by analyzing TCGA datasets. (c) The expressions of SOX4 were positively correlated with BAIAP2-AS based on TCGA datasets. (d) The expression of miR-361-3p was measured in five HCC cell lines and LO2 cells by RT-qPCR. (e) Survival assays of 362 HCC patients according to SOX4 expression based on TCGA datasets. (f) Luciferase reporter assays were performed to verify the binding of miR-361-3p in 3UTR of SOX4. (g) The HepG2 and PLC5 cells transfected with miR-361-3p mimics exhibited an increased expression of SOX4. .

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