Research Article
Nonalcoholic Fatty Liver Disease-Associated Liver Fibrosis Is Linked with the Severity of Coronary Artery Disease Mediated by Systemic Inflammation
Table 1
Baseline characteristics of NAFLD patients with and without CAD.
| | Variables | Non-CAD () | CAD () | value |
| | Clinical characteristics | | | | | Age (year) | | | <0.001 | | Male, (%) | 96 (33.7) | 141 (57.3) | <0.001 | | Smoking, (%) | 50 (17.5) | 91 (37.0) | <0.001 | | Hypertension, (%) | 147 (51.6) | 163 (66.3) | 0.001 | | DM, (%) | 70 (24.6) | 90 (36.6) | 0.003 | | Laboratory data | | | | | Neutrophil (109/L) | | | <0.001 | | Lymphocyte (109/L) | | | 0.37 | | Monocyte (109/L) | | | <0.001 | | NLR | | | <0.001 | | Platelet (109/L) | | | 0.88 | | AST (U/L) | 23 (18, 29) | 24 (19.0, 40.1) | 0.006 | | ALT (U/L) | 24 (17.0, 37.5) | 26 (18.0, 39.2) | 0.201 | | GGT (U/L) | 32 (22.4, 50.0) | 33 (25.4, 51.2) | 0.225 | | Total protein (g/L) | | | 0.02 | | Albumin (g/L) | | | <0.001 | | TBIL (μmol/L) | | | 0.98 | | DBIL (μmol/L) | | | 0.75 | | GLU | | | <0.001 | | HbA1c (%) | | | <0.001 | | Creatinine (μmol/L) | | | <0.001 | | Uric acid (μmol/L) | | | 0.05 | | Cys C (mg/L) | | | 0.02 | | Cholesterol (mmol/L) | | | 0.99 | | Triglyceride (mmol/L) | | | 0.09 | | HDL (mmol/L) | | | <0.001 | | LDL (mmol/L) | | | 0.65 | | Fibrosis markers | | | | | FIB-4 | 1.23 (0.96, 1.63) | 1.43 (1.10, 2.09) | <0.001 | | APRI | 0.30 (0.23, 0.40) | 0.34 (0.23, 0.53) | 0.004 |
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Values are expressed as , no. (%), or median (interquartile range). CAD: coronary artery disease; DM: diabetes mellitus; NLR: neutrophil-to-lymphocyte ratio; ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: γ-glutamyl transpeptidase; Cys C: Cystatin C; TBIL: total bilirubin; DBIL: direct bilirubin; HDL: high-density lipoprotein; LDL: low-density lipoprotein. |
