Research Article

Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma

Table 2

Pathway enrichment analysis of differentially expressed genes among the FAM83 family.

KEGG pathwayFold enrichment valueRelated genes

FAM83A
ECM-receptor interaction23.282973.10-05LAMB3, ITGB6, ITGB4, LAMC2, ITGA3
Focal adhesion11.676235.80-05LAMB3, ITGB6, ITGB4, LAMC2, ITGA3, FLNB
Pathways in cancer4.7701690.037837LAMB3, SLC2A1, LAMC2, ITGA3
FAM83D
Cell cycle26.151431.24-10CCNB1, CDK1, CCNB2, PLK1, BUB1, BUB1B, TTK, CDC25C, CCNA2
Oocyte meiosis23.113641.36-07CCNB1, CDK1, CCNB2, PLK1, BUB1, AURKA, CDC25C
p53 signaling pathway21.365555.94-04CCNB1, CDK1, CCNB2, RRM2
FAM83E
Axon guidance4.1252030.001289SEMA4G, EFNA1, EFNA2, CFL2, EFNB1, MAPK3, PPP3CB, EFNA4, CXCL12
Tight junction3.9712770.001647CLDN7, MPDZ, CGN, CRB3, MYH14, AMOTL1, TJP3, SRC, AKT3
Glycosphingolipid biosynthesis9.4604650.00795FUT6, FUT3, B3GNT3, FUT2
ErbB signaling pathway4.0777870.014669CBLC, ERBB2, MAPK3, MAPK10, SRC, AKT3
Fc gamma R-mediated phagocytosis3.7343940.020746MARCKSL1, CFL2, MAPK3, VASP, AKT3, DNM2
VEGF signaling pathway3.941860.036037PLA2G10, MAPK3, PPP3CB, SRC, AKT3
Adherens junction3.8394740.039139FGFR1, ERBB2, MAPK3, TCF7L2, SRC
FAM83H
Axon guidance3.7422733.61-05NGEF, EFNB1, EPHB4, CXCL12, EPHA2, SLIT3, SEMA5A, SEMA3G, FYN, CFL2, RAC1, PPP3CB, SEMA4B, EFNA4, RHOD
Cell adhesion molecules (CAMs)2.9257770.002361F11R, CLDN7, SDC1, CLDN4, CD34, NRXN3, PECAM1, NLGN4X, JAM2, SDC4, NEGR1, CDH5
Calcium signaling pathway2.3771940.007799SLC8A3, EDNRB, PLCB3, SLC8A1, PTGER3, ADORA2A, TACR1, ERBB2, PDE1A, PPP3CB, PLCD3, PTGFR, ITPR1
Tight junction2.6419330.008055F11R, EPB41L3, CLDN7, CTTN, CLDN4, MPDZ, CGN, MYH14, JAM2, TJP3, MYH10
Leukocyte transendothelial migration2.7274190.010253F11R, CLDN7, CLDN4, PECAM1, RAC1, RAPGEF4, JAM2, CXCL12, CDH5, VASP
Pathways in cancer1.668050.04474CKS1B, FGFR1, ERBB2, STAT5B, SMAD4, ITGA3, BCL2L1, MAPK10, FZD4, JUP, CBLC, LAMB3, BCL2, RAC1, PIAS2, TRAF4, GSTP1