mtDNA in the Pathogenesis of Cardiovascular Diseases

Table 1

Cardiovascular diseases associated with pathogenic mtDNA mutations.

Mutation type	Mutant gene mutations in the genes	Disease	Reference
Basepair substitution	mtDNA A4401G	Hypertension	[50]
	mtDNA T14484G		[51]
tRNA genetic mutation	tRNA^Met m.A4435G; tRNA^Leu m.A3243G; tRNA^Leu m.A4263G; tRNA^Leu m.T4353C; tRNA^Phe m.C593T; tRNA^Trp m.C5553T; tRNA^Glc m.T4353C; tRNA^Ile m.T4291C; tRNA^Leu m.T3253C; tRNA^Ala m.A5655G		[52–58]
mRNA mutation	m.A8701G in ATP6		[59]
tRNA genetic mutation	tRNA^Thr m.G15927A; tRNA^Phe m.T5592C; tRNA^Leu m.A3243G	Coronary atherosclerotic disease	[60]
mtDNA deletion	mtDNA4977bp; Deletion		[61]
Basepair substitution	mtDNA T16189C		[62]
mtDNA deletion	mtDNA4977bp; Deletion	Arrhythmia	[63]
Basepair substitution	mtDNA T14709C	Cardiomyopathy	[64]
tRNA genetic mutation	tRNA^Alle m.4322dupC		[65]
	tRNA^Leu m.A3243G		[66]
mtDNA rearrangement deletion	7.5 KB deletion between ATPASE6 gene and D loop		[67]
	mtDNA7436bp; Deletion		[67]
tRNA genetic mutation	tRNA^Leum.A3243G	Heart failure	[68]