Identification of Neuropeptides as Potential Crosstalks Linking Down Syndrome and Periodontitis Revealed by Transcriptomic Analyses

Table 2

The topological characteristics of the top 30 nodes with the greatest degree in the PPI.

Name	Label	Degree	Average shortest path length	Betweenness centrality	Closeness centrality	Topological coefficient
TP53	Cross	1079	2.251789	0.420797	0.444091	0.002318
FN1	Cross	818	2.451365	0.305578	0.407936	0.003156
HSPD1	Cross	275	2.381129	0.095272	0.419969	0.005405
CASP3	Cross	196	2.800159	0.058752	0.357123	0.009409
KAT2B	Cross	194	2.632123	0.057222	0.379921	0.006785
TXN	Cross	132	2.612775	0.037883	0.382735	0.009874
TNF	Cross	129	2.909091	0.04546	0.34375	0.012626
TUBB2A	Cross	124	2.68036	0.035164	0.373084	0.009755
CCND1	Cross	121	2.916247	0.028949	0.342906	0.01551
CLU	Cross	116	2.814471	0.036914	0.355307	0.012297
TGFB1	Cross	105	2.953883	0.037888	0.338537	0.018972
PDGFRB	Cross	100	3.001855	0.029277	0.333127	0.029775
ENO2	Cross	98	2.971376	0.025504	0.336544	0.019222
APPL1	Cross	94	2.7066	0.033818	0.369467	0.012009
WNK1	Cross	92	3.028359	0.029407	0.330212	0.027433
HYOU1	Cross	80	2.986483	0.020004	0.334842	0.023633
UBC	Cross	72	2.118208	0.170684	0.472097	0.020807
APOE	Cross	70	2.999205	0.022849	0.333422	0.027381
ITGB2	Cross	62	2.994699	0.01851	0.333923	0.03201
TSPAN5	Cross	61	3.040021	0.027445	0.328945	0.020492
NOD2	Cross	54	3.06626	0.015464	0.32613	0.032764
SERPINA1	Cross	52	2.786112	0.016528	0.358923	0.021452
ERCC2	Cross	51	2.750066	0.013578	0.363628	0.02154
NEFL	Cross	49	2.994964	0.013643	0.333894	0.027498
RAB4A	Cross	49	2.749536	0.016342	0.363698	0.021511
CCR5	Cross	47	3.181818	0.011847	0.314286	0.032499
GHR	Cross	47	3.042937	0.009512	0.32863	0.043566
GZMB	Cross	45	2.9022	0.009937	0.344566	0.024898
SLC1A5	Cross	45	3.067851	0.01041	0.325961	0.047009
CTSG	Cross	41	2.967135	0.01082	0.337025	0.026546