Upregulated Transcription Factor PITX1 Predicts Poor Prognosis in Kidney Renal Clear Cell Carcinoma-Based Bioinformatic Analysis and Experimental Verification

Table 3

Univariate and multivariate Cox regression analyses of clinical characteristics associated with overall survival.

Characteristics	Total ()	Univariate analysis		Multivariate analysis
		Hazard ratio (95% CI)	value	Hazard ratio (95% CI)	value
Gender (female vs. male)	539	1.075 (0.788-1.465)	0.648
Age (≤60 vs. >60)	539	0.567 (0.417-0.770)	<0.001	0.565 (0.369-0.866)	0.009
Race (black or African American vs. white)	524	0.856 (0.464-1.579)	0.618
T stage (T3+T4 vs. T1+T2)	539	3.228 (2.382-4.374)	<0.001	1.695 (0.742-3.871)	0.211
N stage (N1 vs. N0)	257	3.453 (1.832-6.508)	<0.001	1.425 (0.701-2.896)	0.328
M stage (M1 vs. M0)	506	4.389 (3.212-5.999)	<0.001	2.949 (1.721-5.053)	<0.001
Pathologic stage (stage III+IV vs. stage I+II)	536	3.946 (2.872-5.423)	<0.001	1.081 (0.423-2.761)	0.871
Histologic grade (G3+G4 vs. G1+G2)	531	2.702 (1.918-3.807)	<0.001	1.638 (0.993-2.700)	0.053
PITX1 (high vs. low)	539	2.713 (1.959-3.757)	<0.001	1.998 (1.261-3.165)	0.003

Statistical significance . CI: confidence interval.